Usually a period of time lapses after biopsy and before surgery which allows the tumor to “bud”, in other words, GROW from the puncture site, which is apparently now an important feature in determining how aggressive to be with treatment! The more “budding”, the more aggressive treatment may be.

This article in Honest Pathology entitled What Does Tumor Budding Mean discusses this phenomena and refers to the puncture site as “the invasive front” of the tumor (rather than as “the invaded front” go figure) where the tumor is most likely to bud and invade surrounding tissue! The rate of budding from the biopsy site is considered a cancer marker of the tumor’s aggressiveness per the article, so it is the pathologist’s job to report about the quality and quantity of budding at the biopsy poke site after the tumor is removed and reaches the lab in order to help determine how aggressive treatment should be.

The big takeaway from this is how dangerous it may be to leave a biopsied tumor in place which is exactly what happens when a woman decides that she will treat naturally instead of proceeding with surgical removal. If there is any chance a person will want to treat naturally, a “stab and grab” biopsy should be considered a possible hinderance to the natural treatment’s ability to work because it tends to induce budding/growth. An excisional biopsy does not; an excisional biopsy removes the entire mass and entire tumor is sent off to the lab for determination of its type.